Want better gut health fast? Targeted synbiotic release delivers probiotics, prebiotics, and postbiotics directly where they're needed most - your gut. Here's how it works:
- The Problem: Probiotics often fail due to stomach acid and digestion.
- The Solution: Advanced delivery systems like lipid-coated microencapsulation and Lyosublime™ protect and release 500 billion CFU probiotics effectively without refrigeration.
- Proven Results: 94% less bloating in 7 days, 87% fewer allergies, and improved gut bacteria balance.
Quick Tech Overview:
- Freeze-Drying: Keeps probiotics stable.
- Lyosublime™: Direct absorption, no capsules.
- Starch-Based Release: Timed prebiotic delivery.
These breakthroughs are reshaping gut health, offering faster relief and better outcomes. Read on for the science behind it.
Probi Digestis® probiotic mode of action - Explainer video
How Targeted Release Works
Targeted release systems use a multi-layered approach to protect and deliver synbiotics directly to the gut. This method ensures precise delivery to the intended site.
Protection Against Digestive Challenges
The digestive system can break down and weaken probiotics before they reach their target. To combat this, advanced microencapsulation with lipid coatings is used. This protective layer keeps probiotics alive and potent during digestion, even without refrigeration, ensuring they remain effective.
Controlled Release Mechanisms
After protection, controlled release methods come into play. These include time-based and pH-sensitive systems that ensure synbiotics are delivered exactly where they're needed. The Lyosublime™ delivery system, for example, allows for quick and accurate absorption in the gut without depending on capsule breakdown, maximizing their impact.
Advanced Coating Technology
Seven out of the nine probiotic strains are safeguarded with a lipid-based microencapsulation system. This coating shields them from harsh digestive conditions, stabilizes them, and ensures precise timing for their release. This process ensures the delivery of the full 500 billion CFU to the gut, complemented by targeted prebiotics, enabling a complete microbiome reset.
Current Delivery Technologies
Modern delivery methods ensure synbiotics remain effective until they reach the gut, focusing on precise absorption and maintaining potency.
Freeze-Drying Process
Freeze-drying, also known as lyophilization, removes moisture while keeping probiotics intact. This process freezes probiotics and removes water through sublimation, resulting in a stable powder that doesn't require refrigeration. Clinical studies have shown this technique can significantly reduce bloating, paving the way for better absorption methods.
Lyosublime™ Technology
Lyosublime™ takes delivery a step further by removing traditional capsule barriers, allowing probiotics to be absorbed directly throughout the digestive system.
"Our divine 3-in-1 superpowder ensures faster absorption throughout the entire gastrointestinal tract. Lyosublime™ Delivery also concentrates higher quantities of bacteria to improve biological efficacy - 500 billion CFU, ensuring maximum potency to deliver greatest benefits–no refrigeration necessary."
- Begin Rebirth RE-1™ Website
This system delivers a concentrated dose of 500 billion CFU per serving, enhancing effectiveness.
Starch-Based Release
Starch-based systems manage the release of prebiotic fibers. Each serving includes 4.5 g of prebiotic fiber, featuring specialized types like GOS (Galacto-oligosaccharides) and Inulin. Together, these methods optimize synbiotic delivery.
| Delivery Technology | Key Benefits |
|---|---|
| Freeze-Drying | Preserves probiotic viability |
| Lyosublime™ | Enables direct absorption |
| Starch-Based | Regulates prebiotic release |
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Proven Results
Microbiome Balance
Clinical research highlights the effectiveness of Begin Rebirth RE-1™ and its Lyosublime™ technology in promoting gut health. Studies on Bifidobacterium breve M-16V show an increase in beneficial bifidobacteria and a decrease in potentially harmful Enterobacteriaceae. These changes align with measurable improvements in health markers.
Measuring Success
These health markers provide a snapshot of the system’s impact:
| Health Marker | Observed Improvement | Timeframe |
|---|---|---|
| Digestive Comfort | 94% reduction in bloating | 7 days |
| Immune Response | 87% decrease in allergies and infections | 7 days |
| Bacterial Balance | Increased levels of beneficial bacteria | 7 days |
| User Satisfaction | 97% recommendation rate; 4.9 out of 5 stars | Ongoing |
The system also boosts natural killer (NK) cell activity and promotes the production of anti-inflammatory cytokine interleukin-10 (IL-10), thanks to prebiotic ingredients like galactooligosaccharide (GOS).
Health Benefits
Beyond lab results, these targeted synbiotics provide noticeable everyday benefits. For example, Lactobacillus gasseri has been linked to better sleep quality in adults with mild stress, while Lactobacillus paracasei BR-MCC1849 can enhance resistance to common colds.
"RE-1 keeps me energized all day. The boost in clarity and stamina is real. It's my must-have travel essential - powerful protection against harmful bacteria and viruses. I feel much safer having it with me. Definitely worth the investment."
– S R., Verified Buyer
Looking Ahead
Advances in nanotech encapsulation and pH-responsive coatings are improving the precision and effectiveness of targeted synbiotic delivery. For example, smart hydrogels are now achieving probiotic survival rates as high as 92%, while pH-responsive systems allow for precise targeting within the intestines. These developments are refining existing delivery methods to improve accuracy and outcomes.
Begin Rebirth's Lyosublime™ technology is pushing these advancements even further. This process can preserve up to 500 billion CFU per serving for 12 months, a major leap compared to conventional methods, which typically retain only 50–60% survival and experience up to 30% degradation.
| Delivery Innovation | Current Impact | Future Potential |
|---|---|---|
| Smart Hydrogels | 92% survival rate | Site-specific activation |
| Nano-encapsulation | Enhanced stability | Targeted organ delivery |
| pH-responsive Coatings | Precise release timing | Customized absorption |
Personalized synbiotic delivery is emerging as the next big step. With gut pH testing, customized coating formulations are becoming a reality. Early trials have shown a 44% boost in beneficial bacteria levels when compared to standard methods. These advancements point toward fully individualized microbiome solutions by 2026.
Regulations are also evolving. The FDA's draft guidance for 2024 on Live Biotherapeutic Products could require proof that at least 80% of CFU are viable both at ingestion and during release in the intestines. This would establish new benchmarks for delivery effectiveness.
Incorporating postbiotics is becoming increasingly important as well. Meta-analyses show that synbiotics enriched with postbiotics can speed up IBS symptom relief by 31% compared to probiotic-only options. This indicates that future delivery systems may focus on protecting and releasing live cultures alongside their beneficial metabolites.
Meanwhile, ongoing NIH trials are testing delayed-release coatings designed to bypass the stomach's acidic environment entirely. These coatings could potentially reduce antibiotic-associated diarrhea by up to 70% in high-risk patients, highlighting the clinical benefits of improving delivery technologies.
FAQs
How does Lyosublime™ technology enhance the delivery and effectiveness of probiotics?
Lyosublime™ technology is designed to optimize the delivery of probiotics by preserving their potency and ensuring they reach the right areas in the body. This advanced system protects the probiotics during storage and transit through the digestive tract, allowing them to remain active and effective upon reaching the gut.
By maintaining the integrity of the probiotics and enabling precise, targeted release, Lyosublime™ helps maximize absorption and supports the restoration of a balanced gut microbiome. This innovative approach ensures better results compared to traditional delivery methods.
What are the health benefits of using targeted synbiotic delivery systems?
Targeted synbiotic delivery systems are designed to release beneficial prebiotics, probiotics, and postbiotics directly where they are most needed in the body, such as specific areas of the gut. This precise delivery can help restore gut microbiome balance, support immune health, and improve digestion.
For example, Begin Rebirth RE-1™ uses an advanced Lyosublime™ delivery system to ensure optimal absorption and effectiveness. By addressing gut imbalances like dysbiosis, these systems can contribute to overall health and well-being, offering a more focused and efficient approach to microbiome care.
How do advanced delivery systems protect probiotics and ensure they reach the gut effectively?
Advanced delivery systems, such as specialized coating technologies, are designed to protect probiotics as they travel through the harsh conditions of the digestive system. These coatings shield the probiotics from stomach acid and bile, ensuring they remain viable until they reach the intestines, where they can provide the most benefit.
For example, the Lyosublime™ delivery system used in Begin Rebirth RE-1™ enhances absorption and ensures the probiotics are released precisely where they are needed. This targeted approach helps maximize the effectiveness of the probiotics in restoring gut balance and supporting overall health.