Probiotic stability is essential for their effectiveness. To ensure probiotics work as intended, it’s crucial to manage five key factors:
- Temperature: Modern probiotics can remain stable at room temperature, but extreme temperature changes during storage or shipping can weaken them. Advanced technologies like Lyosublime™ help maintain stability.
- Moisture: High moisture levels degrade probiotics. Using moisture-proof packaging and regulating water activity ensures long-term potency.
- Packaging: Protective, multi-layer packaging shields probiotics from environmental factors like light, oxygen, and moisture.
- Light and Oxygen: Exposure to oxygen and UV light can harm probiotics. Lipid microencapsulation and opaque packaging help protect them.
- Product Formula: A well-designed formula with prebiotics, controlled pH, and advanced preservation methods (e.g., microencapsulation) ensures probiotics remain effective.
Probiotics , Prebiotics and synbiotics
Temperature Control
Managing temperature is crucial for keeping probiotics potent. In the past, refrigeration was necessary, but advancements in biofermentation and strain development have made it possible to store probiotics without it. Begin Rebirth RE-1™ uses its proprietary Lyosublime™ delivery system to maintain high levels of bacteria - up to 500 billion CFU per serving - without needing refrigeration.
Best Storage Temperatures
Thanks to modern methods, probiotics can now stay stable at room temperature, making storage and daily use much easier. However, it's also important to think about how temperature shifts during transport might affect their stability.
Temperature Changes
Fluctuating temperatures during storage or shipping can weaken probiotics. Microencapsulation helps shield the bacteria from environmental stress, preserving their strength even when exposed to temperature changes. For the best results, look for products that incorporate advanced delivery systems, carefully chosen strains, and protective measures.
Moisture Control
Moisture can significantly impact probiotic stability. Keeping water levels in check and using effective moisture barriers are key to maintaining their potency over time.
Water Content Management
Controlling water activity is critical for keeping probiotics effective. Begin Rebirth RE-1™ uses the Lyosublime™ system to concentrate microbes while tightly regulating moisture. This process ensures that each 500 billion CFU serving stays stable and reliable. These measures work hand-in-hand with advanced packaging to protect the product.
Moisture-Proof Packaging
Begin Rebirth RE-1™ comes in sachets with multiple barrier layers, airtight seals, and single-dose portions. This design effectively blocks out ambient moisture, ensuring the probiotics remain stable and protected throughout their shelf life.
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Protective Packaging
Protective packaging adds another layer of security to ensure probiotics remain effective. By using advanced materials and technologies, this packaging helps maintain stability, extend shelf life, and preserve the strength of probiotics.
Types of Packaging Materials
Modern probiotic packaging relies on materials designed to shield probiotics from external factors. For example, Begin Rebirth RE-1™ uses a multi-layer sachet system that keeps its 500 billion CFU formulation stable without refrigeration. These materials form the foundation for smarter solutions that offer even better protection.
Smart Packaging Features
Smart packaging goes a step further by incorporating technology to protect probiotics. One example is microencapsulation, which uses a lipid coating to guard probiotic strains from environmental challenges.
Begin Rebirth RE-1™ includes the following smart packaging features:
- Multi-layer barrier system: Reduces exposure to harmful environmental elements.
When combined with the Lyosublime™ system, these features help maintain the probiotic's strength and improve absorption. This ensures the product stays effective from manufacturing to consumption.
Light and Oxygen Protection
Oxygen and light exposure can harm probiotics, reducing their effectiveness. To keep probiotics working properly, specific steps are needed to shield them from these environmental factors.
Protecting Against Oxygen
Oxygen can break down probiotics, making them less effective. Begin Rebirth RE-1™ uses a special microencapsulation process with a lipid coating to reduce oxygen-related damage. Additionally, the Lyosublime™ delivery system keeps the product stable at room temperature while ensuring it is absorbed well in the digestive system.
Shielding from Light
Like oxygen, light - especially UV light - can weaken probiotics. To prevent this, opaque packaging is used to block harmful UV rays. Smart packaging features also add extra layers of protection, safeguarding Begin Rebirth RE-1™ from light exposure and other environmental factors.
Product Formula Design
In addition to packaging and environmental controls, the way a product is formulated plays a crucial role in maintaining probiotic effectiveness. The stability of probiotics hinges on the formulation and manufacturing techniques used.
Ingredient Selection
Choosing the right ingredients is key to keeping probiotics stable. Begin Rebirth RE-1™ includes specific prebiotics - Galactooligosaccharide (GOS) and Inulin, providing 4.5 g of fiber - that work in tandem with its probiotic strains.
Here are some of the most important factors:
- pH balance: Ensuring the right acidity levels during production to stop premature bacterial activation.
- Growth factors: Carefully managing 28 critical growth parameters during biofermentation to keep the strains viable.
- Culture medium: Using meat-free and dairy-free media to maintain product purity while supporting bacterial growth.
Equally important is how these ingredients are preserved.
Preservation Methods
Begin Rebirth RE-1™ uses advanced methods to ensure probiotics remain stable:
- Microencapsulation: Seven of the nine probiotic strains are coated with a specialized lipid layer for added protection.
- Lyosublime™ delivery system: This proprietary technology concentrates microbes and improves absorption.
The manufacturing process is rigorous, with over 50 QA/QC checkpoints to ensure purity and strength, all adhering to U.S. and EU standards. Facilities also follow strict GMP and HACCP guidelines.
These efforts are paying off. A third-party study found that 94% of participants experienced less bloating and abdominal pain after just 7 days of using the formula.
Conclusion
Effectively managing the five main factors that influence probiotic stability is key to supporting IBD. These factors include controlling temperature, managing moisture, using protective packaging, shielding from light and oxygen, and ensuring a well-designed formula. Together, they help keep probiotics potent and effective.
Modern delivery systems can now keep probiotics stable without refrigeration, offering concentrations as high as 500 billion CFU per serving throughout a product's shelf life. This advancement has greatly enhanced the potential of probiotics in managing IBD.