Antibiotics

Over the last century, urban-stressors have disrupted up to 50% of our human microbiome, depleting the maternal protection we're born with—Human Origin Strains (HOSt®).*

Antibiotics

Herbicides

Pesticides

Low Fiber

Ultra Processed Foods

Nutrition Deficiencies

Alcohol

C-section Births

Travel Disturbances

Chronic Stress

Endocrine Disruptors

Sleep Disturbances

Medications

Nature Deprivation

Lack of Exercise

Environmental Toxins

Dietary Monotony

GMO's

Artificial Sweeteners

BPA's

Chlorinated Water

High-Fructose Corn Syrup

PFOAs (Forever Chemicals)

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RE-1™ Restore Eublosis

In the last 100 years, we have lost approximately 50% of our human gut microbiome. Our oldest ally and critical defence system is vanishing.

Hyper Urbanization Era

1945: Green Revolution Era1

The climax of widespread use of synthetic fertilizers and pesticides. And the development of genetically modified crops.

Broad Spectrum Antibiotics

1970: Broad Spectrum Antibiotics Discovered2

The emergence of antibiotic-resistant bacteria becomes a significant public health issue. The vast majority of antibiotics given to farm animals for human consumption.

Loss of Generational Transmission

1985: Loss of Generational Transmission3

C-section delivery rates increased by 400%. Babies born by Caesarean section have dramatically depleted microbes.

Hygiene Hypothesis

1989: Hygiene Hypothesis4

David P. Strachan, British epidemiologist, hypothesized that reduced exposure to pathogens in early childhood leads to an increased risk of allergic diseases.

Hygiene Hypothesis

2000: Hyper Urbanization Era5

50% of the world population are now urban city dwellers. Humans that live in urban environments have lost approximately half their gut microbiota.

citations

  1. Gama J, Neves B, Pereira A. 2022. Chronic Effects of Dietary Pesticides on the Gut Microbiome and Neurodevelopment. Front Microbiol.
  2. Blaser, Martin J. 2014. Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues. Henry Holt and Co, First Edition.
  3. Shan, Y., Forster, S.C., Tsailki, E. et al. 2019. Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth. Nature.
  4. Strachan D. P. 1989. Hay fever, hygiene, and household size. BMJ.
  5. Bruchett S, Sinha T, et al. 2020. The Effects of Urbanization on the Infant Gut Microbiota and Health Outcomes. Frontier Pediatric.

Unparalleled Protection

Clean Label
GMP-Certified
Clinically Proven
Third-Party Tested
Made in Japan
Non-GMO
100% Traceable

FORMULATED ON OVER 5O+ YEARS OF RESEARCH

RE-1™ arose from the discovery that the Human Origin Strains (HOSt®) we inherit at birth are vital for whole-body vitality and lasting immune protection.

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RE-1™ Restore Eubiosis

Human Origin Strains (HOSt™)

Human Origin Strains—HOSt™ are live, bioidentical microbes present during a healthy human birth. These resident strains differ from transient probiotics—from animals and plants, which pass through the digestive system without permanent colonization, leading to disruptions and imbalances. This is called Dysbiosis.

The composition of our microbiome is established by transmission of foundational human strains naturally at birth. This is called Generational Transmission

HOSt™ form the foundation of the gut microbiome and are the immune system’s principal protectors, defending against daily disruptors. RE-1™ contains clinically validated ingredients to establish a microbiome flourishing with HOSt™–allowing your immune system to be supported by its oldest allies and most precious protectors. These strains exhibit superior physiological functions to establish and maintain balance. This is called Eubiosis.

80% of those living in urban environments - missing Human Origin Strains (HOSt™) have experienced daily gut disturbances in the past 30 days.

Pie Chart showing 80% disturbed and 20% undisturbed
Figure 1. In a third-party, single-arm, observational study of 35 adults ages 20-65 years old conducting a self-assessment on gut health and daily disturbances over a 30 day period. 80% of participants reported daily gut disturbances.

CITATIONS

*Wong CB, et al. 2018. Different physiological properties of human-residential and non-human-residential bifidobacteria in human health. Benef Microbes.
¹In a third-party, single-arm, observational study of 35 adults ages 20-65 assessing self-reported gut disturbances over 30 days.

AN EVOLUTION IN GUT HEALTH & IMMUNE PROTECTION

The first clinically-backed microbiome reset—RE-1™ is a potent 3-in-1 formula of human-origin probiotics, prebiotics, and postbiotics designed to restore harmony, radiance and resilience, from within.

7 live Human Origin Strains (HOSt®) bioidentical to those received at birth — clinically studied to defend and repopulate your microbiome.

Bifidobacterium longum BR-BB536, Bifidobacterium breve BR-M16V, Bifidobacterium infantis BR-M63, Bifidobacterium breve BR-B3, Lactobacillus gasseri BR-LAC-343, Bacillus coagulans BR-LACRIS-S, Lactobacillus helveticus BR-MCC1848.

Probiotic Formulation

4.5 g of Galactooligosaccharide + Inulin to nourish beneficial flora and enhance postbiotic metabolite production.

Prebiotic Complex

1 immunogenic Human Origin Strain (HOSt®) stimulates immune signaling molecules (cytokines) to regulate inflammation and strengthen resilience.

Lactobacillus paracasei BR-MCC1849

Postbiotic Formulation
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RE-1™ Restore Eubiosis

Nutrition Facts

Serving Size 1 Sachet (5g powder)
Servings Per Pack 7

Amount Per Serving % Daily Value for Adults 18 Yrs+ % Daily Value for Children 3 Yrs+
Calories 19 1% 2%
Total Carbohydrate 4.7g 2% 4%
Dietary Fiber 5g 18% 36%
Total Sugars
Includes 0g Added Sugars**
Prebiotic Galactooligosaccharide (GOS) + Inulin (Low Molecular Weight) 5g

Probiotic Strains + Postbiotic Strain

Bifidobacterium longum BR-BB536, Bifidobacterium breve BR-M16V, Bifidobacterium infants BR-M63, Bifidobacterium breve BR-B3, Lactobacillus gasseri BR-LAC-343, Bacillus coagulans BR-LACRIS-S, Lactobacillus helveticus BR-MCC1848, Lactobacillus paracasei BR-MCC1849

Total Probiotic Enumeration

500 Billion CFU

*Percent Daily Value (%%DV) is based on a 2,000 calorie diet.

‡Percent Daily Value (%%DV) is based on a 1,000 calorie diet.

**Contains naturally occurring sugars.

CFU = Colony Forming Units (indicator of probiotic viable cell count)

For Optimal Results: Consume 1 sachet with water daily in the morning on an empty stomach.

Feel the difference. Fast.

AFTER 7 DAYS¹

  • 94%

    felt less bloating & abdominal pain¹

  • 87%

    noticed fewer allergies & infections¹

¹Conducted on 35 healthy adults ages 25-65 assessing the self-perceived efficacy of RE-1™ over 7 days.

Whole-body benefits in every sachet.

RE-1™ is specifcally formulated to support:

Dermatological Health

Digestive health

Oral Health

Psychological Health

Respiratory Health

Urogenital Health

Immune Health

Promotes healthy skin hydration and resilience*
Supports skin clarity and reduction of blemishes*
Enhances the skin's natural barrier function against environmental stressors*

Reinforces healthy stool hydration and ease of evacuation*
Supports gut ease from occasional gastrointestinal discomfort associated with increased intestinal transit time*

Supports gum health and reduces oral discomfort*
Promotes fresh breath and oral hygiene*
Reinforces healthy teeth and enamel strength*

Supports emotional balance and a positive mood*
Promotes mental clarity and cognitive function*
Helps ease occasional stress and anxiety*

Supports clear, healthy airways and breathing*
Promotes respiratory comfort and defense against environmental irritants*
Reinforces healthy lung function and oxygenation*

Supports urinary tract health and function*
Promotes healthy bladder activity and comfort*
Enhances natural defenses against urinary discomfort*

Supports the body's natural immune response*
Promotes healthy immune system function and resilience*
Reinforces defenses against occasional seasonal challenges*

Whole-body benefits in every sachet.

RE-1™ is specifcally formulated to support:

Dermatological Health
Digestive health
Oral Health
Psychological Health
Respiratory Health
Urogenital Health
Immune Health

Rapid Microbiome Optimization

RE-1™ is specifcally formulated to support:

beyound-images

Dermatological Health

Promotes healthy skin hydration and resilience*
Supports skin clarity and reduction of blemishes*
Enhances the skin's natural barrier function against environmental stressors*

beyound-images

Digestive health

Reinforces healthy stool hydration and ease of evacuation*
Supports gut ease from occasional gastrointestinal discomfort associated with increased intestinal transit time*

beyound-images

Oral Health

Supports gum health and reduces oral discomfort*
Promotes fresh breath and oral hygiene*
Reinforces healthy teeth and enamel strength*

beyound-images

Psychological Health

Supports emotional balance and a positive mood*
Promotes mental clarity and cognitive function*
Helps ease occasional stress and anxiety*

beyound-images

Respiratory Health

Supports clear, healthy airways and breathing*
Promotes respiratory comfort and defense against environmental irritants*
Reinforces healthy lung function and oxygenation*

beyound-images

Urogenital Health

Supports urinary tract health and function*
Promotes healthy bladder activity and comfort*
Enhances natural defenses against urinary discomfort*

beyound-images

Immune Health

Supports the body's natural immune response*
Promotes healthy immune system function and resilience*
Reinforces defenses against occasional seasonal challenges*

Lyosublime™
Delivery System

Formulated to flourish

Requires no breakdown of a capsule barrier, ensuring fastest absorption throughout the entire gastrointestinal tract. Lyosublime™ delivery also concentrates higher quantities of microbes to improve biological efficacy—500 billion CFU, ensuring maximum potency to deliver optimum benefits—no refrigeration necessary.

image-RE-1™  <br> Restore Eubiosis

RE-1™
Restore Eubiosis

Probiotic

Formulated with live Human Origin Strains HOSt® bioidentical to those received at birth, clinically researched by our world-class scientists in Japan and validated by academic institutions in Switzerland, Italy, and USA.

Prebiotic

4.5g of fiber per serve. Galactooligosaccharide (GOS) and Inulin—to foster the growth of beneficial metabolites throughout the microbiome.

Postbiotic

An immunogenic Human Origin Strain HOSt® to activate cytokines that help control inflammation and stimulate immune activity, with important regulatory functions, bridging innate and adaptive immunity.

Formulation

500.0 Billion CFU

4.5g Prebiotic Fiber

No Refrigeration Required

Bifidobacterium longum BR-BB536
Bifidobacterium breve BR-M16V
Bifidobacterium infantis BR-M63
Bifidobacterium breve BR-B3
Lactobacillus gasseri BR-LAC-343
Bacillus coagulans BR-LACRIS-S
Lactobacillus helveticus BR-MCC1848

Galactooligosaccharide (GOS) &
Inulin (Low Molecular Weight LMW)

Lactobacillus paracasei BR-MCC1849

Our divine 3-in-1 superpowder ensures faster absorption throughout the entire gastrointestinal tract. Lyosublime™ Delivery also concentrates higher quantities of bacteria to improve biological efficacy—500 billion CFU, ensuring maximum potency to deliver greatest benefits–no refrigeration necessary.

Rigorously monitored to meet the European Food and Safety Authority (EFSA) Standards

Vegan

Gluten-Free

Dairy-Free

Soy-Free

Nut-Free

Shellfish-Free

Sesame-Free

Corn-Free

Sugar-Free

No Binders

Unflavoured

Non-GMO

No BPA's

No Preservatives

Begin with RE-1.
Results from Day-1.

A clinically-proven microbiome reset that restores what urban-stressors have depleted. Targeting the root cause of imbalance for lasting protection, clarity, and vitality.

7-Day Reset

Rapid relief from bloating and fatigue.

$79

4-Week Reset

Enhance gut, brain, skin, and mood with lasting energy.

316 $279

12-Week Reset

Complete microbiome restoration, vitality and long-term protection.

948 $739

Begin RE-1™ Now
Product Image
  • Strain Selection

    We select proven probiotic strains backed by human clinical research, to ensure efficacy, proven safety, and enduring potency—ensuring every dose delivers measurable benefits.

  • Biofermentation

    How bacteria are cultured impacts their viability. We optimize our biofermentation for pH, temperature, and 28 other critical growth factors. Our mediums contain no meat or dairy.

  • Survivability

    7 of the 9 strains are microencapsulated with a lipid coating to further protect from stomach acids, digestive enzymes, and bile salts during digestion. This also means that refrigeration is not required.

  • Testing

    We do extensive lot-to-lot testing at each step and on the final product. With 50+ QA/QC checkpoints, we monitor purity and strength under both US and EU protocols, including GMP + HACCP.

1 of 4

50 years of research + 200 scientific studies.

Bifidobacterium longum BR-BB536
Subject: Visceral Fat Reduction
Source: 2024 - PubMed®
National Library of Medicine (NLM)
Read the paper

B. longum BB536 may reduce visceral fat and total fat levels in healthy normal and overweight adults. BMI and TG levels also showed significant differences between the groups. Participants did not change their daily diet or exercise habits, 16 weeks of probiotic intake showed a positive effect on visceral fat reduction.

Bifidobacterium breve BR-M16V
Subject: Cesarean Delivered Infants
Source: 2017 - PubMed®
National Library of Medicine (NLM)
Read the paper

Bifidobacterium breve M-16V on the gut microbiota of cesarean-born infants. Supplementation resulted in a higher bifidobacteria proportion from day 3/5 until week 8, a reduction of Enterobacteriaceae from day 3/5 till week 12 compared to controls. This was accompanied with a lower fecal pH and higher acetate.

Bifidobacterium infantis BR-M63
Subject: Mental Health & IBS
Source: 2019 - PubMed®
National Library of Medicine (NLM)
Read the paper

Individuals in a community who developed Irritable Bowel Syndrome (IBS) after major floods have significant mental health impairment. B. infantis M-63 is probably effective in improving mental health of victims who developed IBS and this is maybe due to restoration of microbial balance and the gut-brain axis.

Bifidobacterium breve BR-B3
Subject: Inflammation & Colitis
Source: 2024 - PubMed®
National Library of Medicine (NLM)
Read the paper

Bifidobacterium breve effectively colonized the intestinal tract and alleviated colitis symptoms by reducing the disease activity index. Moreover, B. breve mitigated intestinal epithelial cell damage, inhibited the pro-inflammatory factors, and upregulated tight junction (TJ)-proteins.

Lactobacillus gasseri BR-LAC-343
Subject: Quality of Sleep in Adults
Source: 2023 - PubMed®
National Library of Medicine (NLM)
Read the paper

The gut-brain axis is one of the proposed interactions between the brain and peripheral intestinal functions; of particular interest is the influence of food components on the gut-brain axis mediated via the gut microbiome. Meta-analysis indicates significant improvement in sleep quality of adults with mild to moderate stress as an effect of daily consumption of L. gasseri.

Bacillus coagulans BR-LACRIS-S
Subject: Antibiotic-Diarrhea
Source: 2008 - PubMed®
National Library of Medicine (NLM)
Read the paper

Antibiotic-associated diarrhea (AAD) occurs in approximately 25% of patients receiving antibiotics. The results showed an overall reduction in the risk of AAD when probiotics were coadministered with antibiotics. Probiotics are effective for preventing AAD with the number needed to treat to prevent 1 case of diarrhea being 10. Bacillus coagulans appeared to be most effective.

Lactobacillus helveticus BR-MCC1848
Subject: Anxiety & Depression
Source: 2019 - PubMed®
National Library of Medicine (NLM)
Read the paper

Probiotics can benefit the central nervous system via the microbiota-gut-brain axis, which raises the possibility that probiotics are effective in managing depression. MCC1848 ameliorated sCSDS-induced gene expression alterations in signal transduction or nervous system development. These findings suggest that MCC1848 supplementation is useful as a preventive strategy for chronic-stress-induced depression.

Lactobacillus paracasei BR-MCC1849
Subject: Common Cold & Mood in Adults
Source: 2018 - PubMed®
National Library of Medicine (NLM)
Read the paper

Lactobacillus paracasei BR-MCC1849 postbiotic powder or placebo powder once daily for 12 weeks based on the incidence of the common cold. Total number of days of symptoms, and symptom scores of the common cold significantly improved. Lactobacillus paracasei BR-MCC1849 has the potential to improve resistance to common cold infections in susceptible subjects and maintain a desirable mood state, even under mental stress conditions.

Galactooligosaccharide (GOS)
Subject: Improves Immune Function
Source: 2008 - PubMed®
National Library of Medicine (NLM)
Read the paper

GOS significantly increased the numbers of beneficial bacteria, especially bifidobacteria, at the expense of less beneficial groups. Significant increases in phagocytosis, NK cell activity, and the production of antiinflammatory cytokine interleukin-10 (IL-10) and significant reduction in the production of proinflammatory cytokines were also observed. GOS administration resulted in positive effects on both the microflora composition and the immune response.

Inulin (Low Molecular Weight LMW)
Subject: Calcium & Bone Mineralization
Source: 2005 - PubMed®
National Library of Medicine (NLM)
Read the paper

Daily consumption of a combination of prebiotic short- and long-chain inulin-type fructans significantly increases calcium absorption and enhances bone mineralization during pubertal growth. Effects of dietary factors on calcium absorption may be modulated by genetic factors, including specific vitamin D receptor gene polymorphisms.

Designed to deliver rapid benefits.

How do we compare to commercial probiotics?

RE-1™ Synbiotics Probiotics
Human Origin Strains HOSt® - For Healing, Protection and Performance
3-in-1 Eubiotic (Probiotic + Prebiotic + Postbiotic)
50+ Years of Strain Safety & 200+ Scientific Studies
500 Billion CFU (Medical-Grade)
4.5g Prebiotic Fiber (GOS & Inulin)
Lyosublime™ Delivery - From Mouth to Colon
Restores Bioidentical Microbes Missing During C-Section Birth
Replenishes Gut Epithelium in Minimum 7-Days
3rd-Party Tested - For Quality, Purity and Potency
Clinically Proven - For Gut, Skin, Oral, Mental & Immune-Health
Free from Sugar, Artificial Colorants, Flavors and Preservatives
Monitored for Allergens Defined by European Food and Safety Authority (EFSA)
View All

Healing is in your hands.

The future of health begins with protection from our past. Your body remembers balance, it just needs the signals of nature to awaken it. RE-1™ delivers bioidentical probiotics, prebiotics, and postbiotics that rebuild your natural microbial intelligence.

Restoring what urban-stressors have taken away, RE-1™ reactivates your inner defence system, the core of immunity, digestion, and vitality, so you can protect what you love.

Questions? We're here to support

We keep all the questions we are asked
often on our FAQ page.

While most available solutions target only the symptoms in ways that further disturb the human microbiome, RE-1™ addresses the cause—restoration of Human Origin Strains (HOSt™). RE-1™ begins with a 7-Day Reset to rapidly establish an optimal microbiome and continues with 4-Week and 3-Month Regimen— the simple, one-sachet daily protocol to restore eubiosis to the microbiome and defend the immune-system form daily-disruptions.

In a third-party, non-randomized, single-arm study: With daily use for 7 days, RE-1™ was reported to positively stabilize digestion, and strengthen immune-system functioning, and 94% of participants experienced less bloating and 84% experienced less allergies and infections.

RE-1™ is a 3-in-1 medical-grade-eubiotic that has been scientifically formulated and clinically validated to provide benefits to:

• digestive health
• immune defense
• gut barrier integrity
• optimal bowel functioning
• allergy prevention
• micronutrient synthesis
• dermatological health
• cognitive function and mental health
• metabolic function and weight management.

You may access the strain-specific clinical studies associated with each benefit in our Scientific Research.

Every body tells its own story. Some chapters unfold swiftly—like a gentle easing of bloating or a welcome return to regularity, often within 24 to 48 hours. Other transformations—deeper, more profound—may take their time. The quiet fortification of your gut’s defenses, the subtle support of heart health, and the unseen recalibration of your inner ecosystem often unfold beyond the visible horizon.

It’s natural not to feel every benefit. But rest assured, the living microbes are at work—quietly, consistently—nurturing, balancing, and supporting your well-being from within. Daily devotion is key; their work is cumulative, their impact enduring.

Your body is home to trillions of microorganisms, including 100 trillion (1,000,000,000,000) bacteria that live within you. They perform critical functions like digesting food, managing inflammation, and synthesizing key nutrients, metabolites and neurotransmitters. This is your microbiome.

RE-1™ medical-grade-eubiotic is formulated to provide benefits for gut immune function and whole-body health for children age 0+ and adults age 18+.

In the intricate tapestry of our daily existence, RE-1™ emerges as a harmonious elixir, meticulously crafted to fortify the body's natural defenses. Infused with Human Origin Strains HOSt™, to shield our cells from the relentless march of time and urban-aggressors. By embracing RE-1™, one may experience a revitalization of vitality and a profound enhancement of overall well-being. It stands as a testament to the art of thoughtful formulation, inviting you to partake in a ritual of nourishment and protection.

Children (Age 0+) and Adults (Age 18+) consume 1 sachet with water daily in the morning on an empty stomach. Or as directed by your healthcare professional.

As with any dietary supplement or new health protocol contemplated during pregnancy or lactation, we recommend speaking with your physician or obstetrician before you start consuming Begin Rebirth® RE-1™.

Probiotics, in general, do not appear to pose any safety concerns for pregnant and lactating individuals. The current literature does not indicate an increase in adverse pregnancy outcomes when probiotics are used by healthy individuals.

It is recommended to consume RE-1™ for a minimum of 7-days as a rapid reset to alleviate symptoms and immediately establish an optimal gut microbiome.

The 4-week protocol maintains stability and protects against daily disruptions.

The 3-month regimen establishes eubiosis and addresses the root cause of imbalances.

If for any reason you are not satisfied with your purchase, you may request a refund within 30 days of delivery of your order. We’ll refund you for the full cost of the product less shipping, tax and duties - no questions asked.

Real people. Real results.

4.9
Rated 4.9 out of 5 stars
Based on 54 reviews
Total 5 star reviews: 52 Total 4 star reviews: 1 Total 3 star reviews: 1 Total 2 star reviews: 0 Total 1 star reviews: 0
98%would recommend these products
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54 reviews
  • GS
    G S.
    Verified Buyer
    Reviewing
    RE-1™ 12-Week Reset
    I recommend this product
    Rated 5 out of 5 stars
    4 minutes ago
    Excellent product

    After 4 weeks, improvement felt; decided to get 12 weeks to optimise gut health.

  • TO
    Tania O.
    Verified Buyer
    Reviewing
    RE-1™ 4-Week Reset
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    Life Saver

    I recently had a C-section, and if you’ve ever gone through a surgery like that, you know how dreaded the first bowel movement can be. I’ve also struggled with stomach issues for years, but after starting these probiotics, life honestly smiled at me again. My gut feels normal and happy — something I hadn’t felt in ages. This is by far the best probiotic on the market. I’ve tried so many products before, and I can’t believe that in my postpartum recovery, I actually feel better than I ever did before!

  • KK
    Krisdan K.
    Verified Buyer
    Reviewing
    RE-1™ 7-Day Reset
    I recommend this product
    Rated 5 out of 5 stars
    2 weeks ago
    Totally works, feeling great

    I work in the transportation industry and am constantly sharing spaces with the general public; sicknesses are frequent. Since finishing the course I haven't needed a sick day since, and I've been travelling through even more riskier routes. I recommend to all.

  • SS
    Sarah S.
    Verified Buyer
    Reviewing
    RE-1™ 7-Day Reset
    I recommend this product
    Rated 5 out of 5 stars
    2 weeks ago
    Nice surprise

    I felt my tummy settle, less bloat, less cramp, less inconsistency.

    Would have tried month supply if budget allowed, sadly doesn’t.

    Try it out you can’t lose anything, just find something else that might work for your body.

  • M
    Matt
    Verified Buyer
    Reviewing
    RE-1™ 7-Day Reset
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    Feeling good after 7 days

    I just completed the 7 day pack and feel lighter, less bloated and generally good.

    Love the product.

    It tasted great too!